- Science-based nutrition
- Dietary supplement
- Nourishes joint fluid for free and easy movement
Hyal-Joint™ is a patent-pending extract of rooster combs composed of 60% hyaluronic acid, along with collagen and other glycosaminoglycans that form the structural components of connective tissue in joints. Essential for healthy joint function and mobility, hyaluronic acid occurs naturally in the body as a part of synovial fluid, which provides the liquid layer that cushions and lubricates joints.
Puts the spring in your step and the bounce in your walk
Hyal-Joint™ is a patent-pending extract of rooster combs composed of 60% hyaluronic acid along with collagen and glycosaminoglycans that form the structural components of connective tissue.
The Importance of Hyaluronic Acid
Hyaluronic acid, also known as “hyaluronan”, is a large polysaccharide (complex sugar) molecule composed of disaccharides linked together in a chain. It belongs to a family of biological compounds called “glycosaminoglycans” (GAGs). These complex, versatile molecules impart structural strength and integrity to cells while providing elasticity and lubrication to joints and other body parts. GAGs can be thought of as anatomic “glue and grease” that keep bodily structures strong, supple and moving together smoothly.
We are fluid-based organisms; the body––as any biology student knows––contains up to 70% water. Cells have a high water content along with various intracellular organelles. The extra cellular matrix itself is a water world. This non-cellular environment is highly dynamic: a complex bio-field in which cell-to cell-communication and a grand array of other biochemical functions take place.
The extra cellular matrix is also the cushioning and support for joints, the bone-to-bone connections that allow us to move. For this to work according to nature’s design, the spaces between joints need to be viscous as well as fluid; this viscosity keeps friction from building up as joints move harmoniously with each other in their life-long anatomic dance.
Hyaluronic acid is essential for this vitally important viscosity; the “slipperiness” that allows us to move freely and easily. Hyaluronic acid is remarkably viscous: 5000 times more so than water! The synovial membrane, the protective layer surrounding joints, is rich in hyaluronic acid––the pliancy and resiliency of our joints would be non-existent without it; we’d be like the Tin Man waiting for someone to bring us an oil can. When you feel the spring in your step and the bounce in your run, thank nature for hyaluronic acid; you would never experience the joy of movement if it were not for this amazing biological substance that permeates your entire body.
The Importance of Hyaluronic Acid
Intestinal absorption of Hyal-Joint™ has been demonstrated through a laboratory procedure that utilizes spectrophotometric analysis to measure the amount of glycosaminoglycans in tissue cultures.1 Application of this technique to an in vitro model of intestinal absorption produced absorption values of approximately 38,22 and percent in the duodenum, jejunum and ileum, respectively.2 Based on these results, it can be theorized that up to 50 percent or more of the hyaluronic acid in Hyal-Joint™ is absorbed following oral consumption.
(Amounts per Suggested Serving Size)
Helps Maintain Healthy, Smooth Joint Function
The effect of Hyal-Joint™ on joint function and comfort in humans was recently studied in a pilot clinical trial. The study subjects were men and women at least 40 years old who experienced noticeable deterioration of joint comfort on a regular basis.The participants were randomly assigned to take either 80 mg of Hyal-Joint™ or a look-alike placebo capsule every day for eight weeks. Each participant’s joint health and function status was evaluated at the beginning of the trial, and again after four and eight weeks. Assessment was done using the WOMAC Index, a self-administered questionnaire that measures 24 parameters of joint function, and a 36-question survey of physical and mental health and well-being. Statistical analysis of the data showed Hyal-Joint™ to be efficacious for improving physical function, joint comfort and quality of life.1
Nourishes Joint Fluid for Free and Easy Movement
As described earlier, hyaluronic acid is necessary for the synovial fluid to perform its lubricating function in joints. Studies on the intra-articular injection of hyaluronic acid into joints suggest that exogenous HA potentiates endogenous production in synovial fibroblasts (synoviocytes). 2 In a cell culture (in vitro) study, Hyal-Joint™ effectively stimulated endogenous synthesis of hyaluronic acid in synoviocytes.3
It has been observed that a diminished content of hyaluronic acid in joints––with a concomitant loss of its elastic, lubricating benefits–– occurs in tandem with sub-optimal joint health and function.4 As joint health declines, the amount of hyaluronic acid in synovial fluid (intra-articular content) is reduced.5 Hyal-Joint™ was studied for its ability to increase the hyaluronic acid concentration in joints of horses with poorly functioning joints. In a small pilot trial, oral administration of Hyal-Joint™ for 60 days measurably increased both the quantity and quality of hyaluronic acid of the tarsocrural joint (the articulation between the tarsal bone of the foot and the tibia and fibula), while at the same time improving walking ability.6
Does Not Contain: milk, egg, wheat, gluten, corn, soy, sugar, sweeteners, starch, salt, or preservatives.
- Kalman DS, Heimer M,Valdeon A, et al. Effect of a natural extract of chicken combs on pain relief and quality of life in subjects with knee osteoarthritis: a pilot randomized double-blind placebo-controlled trial. Nutrition Journal 2008; 7:3. Click here for study.
- Ghosh P, Guidoli D. Potential mechanism of action of intra-articular hyaluronan therapy in osteoarthritis: are the effects molecular weight dependent? Semin Arthritis Rheum 2002;32(1):10-37. Click here for study.
- Unpublished study conducted at the Rheumatology Service Research Unit; Hopsital Juan Canalejo, L CoruĂ±a, Spain.
- Miltner O, Schneider U, Siebert CH, et al. Efficacy of intraarticular hyaluronic acid in patients with osteoarthritis-a prospectic clinical trial. Osteoarthritis Cartilage 2002;10(9):680-6.
- Brockmeier SF, Shaffer BS. Viscosupplementation therapy for osteoarthritis. Sports Med Arthrosc Rev 2006; 14(3):155-62. Click here for study.
- MartĂnez-Puig D, Carmona JU, ArgĂĽelles D, et al. Oral hyaluronic acid (Hyal-Jointâ„˘) administration improves OCD clinical symptoms and slightly increases intra-articular concentration of hyaluronic acid in a horse model: a pilot survey. Presented at the World Congress on Osteoarthritis. Dec 6-9, 2007; Ft. Lauderdale, FL.
About Doctor's Best
Founded in 1990 by supplement industry veteran Ken Halvorsrude and a wholistic physician, San Clemente-based Doctor's Best, Inc. manufactures and distributes dietary supplements throughout the U.S. and overseas. Doctor's Best is known for high-quality products that are based on sound research in the field of nutritional science.
Keywords: Hyal-Joint, 120 capsules, Doctor's Best