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Doctor's Best

Doctor's Best, SAMe 400, Double Strength, 60 ct

$62.83 $578.43 Free U.S. Shipping over $35Free Shipping
Product Code: DB0252
UPC Code: 753950002524

Suitable for vegetarians

  • Science-based nutrition
  • Dietary supplement
  • Enhances mood and neural function
  • Promotes joint comfort and mobility
  • Supports liver health and body cleansing

Our Double-Strength SAMe 400 contains 400 mg of active SAMe in each tab. Doctor's Best utilizes only the highest quality Italian SAMe available on the market. This ensures that you receive the most potent SAMe product with the highest percentage of the active S,S form per serving, bar none.

S-Adenosyl Methionine (SAMe) is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAMe is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAMe is also required for the biosynthesis of critical neurotransmitters and hormones.

Supplementing with SAMeThe manufacturing process of SAMe yields two forms, the S,S and the R,S isomers. The S,S isomer is the active form that mediates biochemical activity in the human body, whereas the R,S form is considered to be biologically inactive. The Italian SAMe used in Double-Strength SAMe 400 is processed to yield the highest available percentage of the active pure S,S form on the market.

SAMe and Joint FunctionSAMe may enhance cartilage protection and promote the synthesis of proteoglycans, essential components of connective tissue. Clinical studies show an ability of SAMe to enhance mobility and movement, and promote joint comfort.

SAMe and Neural HealthSAMe-catalyzed methylation reactions promote the synthesis of neurotransmitters, which have the potential to promote enhanced mood. SAMe may also upregulate the production of phosphatidylcholine, supporting cognitive function.

SAMe and Liver FunctionSAMe enhances liver synthesis of glutathione, an antioxidant. Glutathione promotes body cleansing and liver protection. Studies show SAMe may protect liver tissue from injury caused by a number of toxins.


60 tabs


SAMe (S-Adenosyl Methionine) is a nutrient unequalled for its health benefits. Doctor's Best Double Strength SAMe 400 and SAMe 200 supply SAMe optimized for potency, stability, and to survive the stomach acid and reach the intestine (where it is absorbed). Doctor's Best SAMe supplements are the best available anywhere.

SAMe's remarkable benefits come from its very high energy content, coupled with its unique molecular structure.1-3The SAMe molecule's high energy facilitates its use as an enzyme cofactor. Literally thousands of enzymes use the energy built into SAMe to overcome energy barriers and thereby to power key metabolic pathways.1-3

SAMe gets its high energy directly from ATP, the body's most highly energized molecule.4Specialized enzymes react ATP with the amino acid methionine to transfer much of ATP's energy into the resulting SAMe molecule.1,2SAMe's chemical energy charge is second only to that of ATP itself.

SAMe's intricate molecular structure amplifies its favorable energy profile. The SAMe molecule provides enzymes with no less than seven different functional groups to power numerous biochemical reactions.1-4Researchers have noted that "no part of the SAMe molecule goes to waste."5SAMe is an essential cofactor for as many as 3,000 human enzymes that between them control a plethora of life processes.3,4

About Doctor's Best

Founded in 1990 by supplement industry veteran Ken Halvorsrude and a wholistic physician, San Clemente-based Doctor's Best, Inc. manufactures and distributes dietary supplements throughout the US and overseas. Doctor's Best is known for high-quality products that are based on sound research in the field of nutritional science.


Do not use if pregnant or nursing. Keep out of reach of children. Please consult your health care provider if currently under care or treatment. Do not exceed recommended serving. See product packaging for additional safety information.


Individual results may vary. This product is not intended to diagnose, treat, cure or prevent any disease. The statements on this website and all affiliates have not been evaluated by the FDA. Advice on treatment or care of an individual patient should be obtained through consultation with a trained health care practitioner.

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